PMID: 9401836Dec 24, 1997

A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies

International Journal of Clinical Pharmacology and Therapeutics
E F DominoP Stetson


The jet injector route for ketamine was used on 30 children 1-6 years of age undergoing various surgical procedures. A randomly selected dose of 2.5, 3.5, or 6.0 mg/kg of ketamine was given to induce anesthesia. Peak plasma ketamine levels did not follow a simple arithmetic increment related to dose. Dosage based on mg/m2 body surface area or mg/kg body weight provided similar blood levels of ketamine. The beta-phase t1/2 of ketamine in these children was shorter than that found in adults. Considerable individual variability was observed in both the plasma levels to a given dose of jet-injected ketamine and in the beta-phase t1/2. The ketamine beta-t1/2s were not dose related.

Related Concepts

Dose-Response Relationship, Drug
Injections, Jet
Ketamine Hydrochloride
Anesthetics, Intravenous

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