A new short-acting non-depolarizing muscle relaxant (SZ1677) without cardiovascular side-effects

Acta Anaesthesiologica Scandinavica
E S ViziH Nagashima

Abstract

In order to facilitate rapid tracheal intubation, the development of a rapid onset, short duration, non-depolarizing muscle relaxant without cardiovascular side-effects would be a significant accomplishment in the field of anesthesiology. The aim of the present study was to test the action of a new non-depolarizing muscle relaxant (SZ1677) on neuromuscular transmission, muscarinic (M2, M3) receptors and cardiovascular reactions and to compare it with clinically used muscle relaxants. Neuromuscular transmission was studied by recording muscle contractions elicited by indirect electrical stimulation, using (i). in vitro isolated phrenic nerve-hemidiaphragm preparation of mice, rats and guinea pigs and (ii). in vivo sciatic nerve-anterior tibial muscle preparation of anesthetized rats, guinea pigs and cats. Cardiovascular effects of muscle relaxants were evaluated on the grounds of their effects on changes of blood pressure and heart rate induced by electrical stimulation of the right vagal nerve in anesthetized cats. To study postsynaptic antimuscarinic affinity of muscle relaxants on M3 receptors, oxotremorine-induced contractions of longitudinal muscle strip of guinea pig ileum were registered in their presence and absence. One...Continue Reading

References

Mar 1, 1975·Anesthesiology·J J Savarese, R J Kitz
Nov 1, 1986·British Journal of Pharmacology·A J Gibb, I G Marshall
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Jan 1, 1994·British Journal of Anaesthesia·B L Appadu, D G Lambert
Jan 1, 1994·Anesthesia and Analgesia·B FredmanP F White
Feb 26, 2000·British Journal of Anaesthesia·K C McCourtD Cochrane
Mar 7, 2000·Anesthesia and Analgesia·T J ZhouT Webb
Jun 5, 2001·Anesthesiology·G H MeakinA M Lynn

Citations

Feb 19, 2009·Anaesthesia·L H D J BooijH D de Boer
Jan 6, 2009·Annals of the New York Academy of Sciences·Mbemba JabbiJohan A den Boer
Aug 13, 2004·European Journal of Pharmacology·M JonssonL I Eriksson
Sep 30, 2003·Pharmacoepidemiology and Drug Safety
Jul 11, 2006·Current Opinion in Anaesthesiology·Gavin J Kilpatrick, Gary S Tilbrook

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