A new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex.

The Journal of Physiology
Karine AbitbolH Daniel

Abstract

In the rodent cerebellum, pharmacological activation of mGluR4 acutely depresses excitatory synaptic transmission at parallel fibre–Purkinje cell synapses. This depression involves the inhibition of presynaptic calcium (Ca2+) influx that ultimately controls glutamate release. In this study, we investigate the molecular basis of mGluR4-mediated inhibition of presynaptic Ca2+ transients. Our results demonstrate that the mGluR4 effect does not depend on selective inhibition of a specific type of presynaptic voltage-gated Ca2+ channel, but rather involves modulation of all classes of Ca2+ channels present in the presynaptic terminals. In addition, this inhibitory effect does not involve the activation of G protein-activated inwardly rectifying potassium channels, TEA-sensitive potassium channels or two-pore-domain potassium channels. Furthermore, this inhibition does not require pertussis toxin-sensitive G proteins, and is independent of any effect on adenylyl cyclases, protein kinase A, mitogen-activated protein kinases or phosphoinositol-3 kinase activity. Interestingly we found that mGluR4 inhibition of presynaptic Ca2+ influx employs a newly defined signalling pathway, notably that involving the activation of phospholipase C an...Continue Reading

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Jan 30, 1987·Biochemical and Biophysical Research Communications·H KaseM Kaneko
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Apr 14, 1999·Journal of Neurophysiology·P KriegerA el Manira
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Mar 21, 2001·Nature Reviews. Neuroscience·S A GoldsteinN Zilberberg
Jun 7, 2002·Current Opinion in Neurobiology·Anatol C Kreitzer, Wade G Regehr
Oct 12, 2002·The Journal of Biological Chemistry·Carmelo MillánJosé Sánchez-Prieto
Feb 25, 2003·British Journal of Pharmacology·Matthias LorezJames N C Kew
Mar 3, 2004·Molecular Interventions·Douglas A BaylissEdmund M Talley
Jun 18, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Solange P BrownWade G Regehr
Feb 3, 2005·British Journal of Pharmacology·Louise E KennardAlistair Mathie
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Isabel AllerStephen G Brickley
Mar 22, 2007·Nature Reviews. Neuroscience·Eric Honoré
Oct 6, 2007·Molecular and Cellular Neurosciences·Stuart M CainTrevor J Bushell

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