PMID: 16510376Mar 3, 2006Paper

A new silymarin preparation based on solid dispersion technique

Advances in Therapy
Ming-feng QiuGuo-xiang Xie

Abstract

Silymarin is a hepatoprotective agent that is poorly soluble in water. The present study describes a new preparation of solid dispersions in the form of "dripping pills" designed to enhance solubility. Dripping pills of silymarin were prepared at a 1:4 ratio by the traditional fusion method with the use of a mixture of silymarin and polyethylene glycol 6000 (PEG 6000). The prepared dripping pills were spherical and 3 to 4 mm in diameter, with an average weight of 30 mg per pill and with each pill containing 5 mg of silymarin. The dissolution rates of silymarin in dripping pill and of 3 other silymarin preparations, including Yiganling Film-Coating Tablet, Yiganling Sugar-Coating Tablet, and Legalon Capsule, were determined in pH 1.2 medium. The dissolution rate (T50) of the silymarin dripping pill was found to be significantly higher (by a factor of 7.5-11) than those of the other 3 preparations.

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Citations

Jun 2, 2009·Chemical & Pharmaceutical Bulletin·Rajeev Garg, Ghanshyam Das Gupta
May 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Minh-Hiep NguyenKunn Hadinoto
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qi ZhangZhenzhen Cai
May 23, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaoyan ChenDafang Zhong
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca SansoneRita Patrizia Aquino
Apr 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ching-Hsuan LiuLiang-Tzung Lin

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