A new soft-matter material with old chemistry: Passerini multicomponent polymerization-induced assembly of AIE-active double-helical polymers with rapid visible-light degradability.

Chemical Science
Jupen LiuYou Yu

Abstract

Mimicking the superstructures and functions of natural chiral materials is beneficial to understand specific biological activities in living organisms and broaden applications in the fields of chemistry and materials sciences. However, it is still a great challenge to construct water-soluble, double-helical polymers with multiple responsiveness. Herein, we report for the first time a straightforward, general strategy to address this issue by taking advantage of Passerini multicomponent polymerization-induced assembly (PMPIA). The polymerization-induced generation of supramolecular interactions in chiral α-acyloxy amides drives the assembly of polymers and improves their stability in various solvents. This double-helical polymer is sensitive to metal ions, temperature, pH, and solvents, making both the superstructure and the AIE effect reversibly adjustable. Meanwhile, the hydrogen-bonding-assisted cyclization of photolabile α-acyloxy amides accelerates the degradation of helical polymers under visible-light irradiation. It is anticipated that this novel PMPIA strategy opens new horizons to inspire the design of advanced chiral/helical polymers with multiple functions.

References

Aug 17, 2004·The Journal of Organic Chemistry·Chitra Sundararajan, Daniel E Falvey
Nov 7, 2007·Journal of the American Chemical Society·Shuxun CuiHermann E Gaub
Sep 8, 2011·Angewandte Chemie·Aaron M Kushner, Zhibin Guan
Aug 9, 2012·Accounts of Chemical Research·Kevin E Riley, Pavel Hobza
Aug 16, 2013·Chemical Communications : Chem Comm·Lei LiZi-Chen Li
Apr 24, 2014·Nanoscale·Meng-Qiang ZhaoFei Wei
Jul 21, 2015·Chemical Reviews·Minghua LiuTianyu Wang
Apr 10, 2016·The Biochemical Journal·Jordi Bella
Jul 7, 2016·Journal of the American Chemical Society·Haodong XueLei Tao
Jul 30, 2016·Journal of the American Chemical Society·Laure V KayserBruce A Arndtsen
Oct 29, 2017·Nature Communications·Huan ZhangRoman Boulatov
Jan 6, 2018·Nature Communications·Sjors P W WijnandsMaarten Merkx
May 1, 2018·Accounts of Chemical Research·Qian WangJieping Zhu
Aug 22, 2018·Journal of the American Chemical Society·Xiang LanYan Liu
Dec 12, 2018·Accounts of Chemical Research·Anthony J Metrano, Scott J Miller
Feb 26, 2019·Angewandte Chemie·Bryan T TutenChristopher Barner-Kowollik
Aug 29, 2019·Journal of the American Chemical Society·Qingqing GaoBen Zhong Tang

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Methods Mentioned

BETA
amidation
circular dichroism
NMR
Fluorescence
fluorescence spectroscopy
AFM
column chromatography
silica gel column chromatography

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