A new sol-gel silica nanovehicle preparation for photodynamic therapy in vitro

International Journal of Pharmaceutics
Lin ZhouJian Shen

Abstract

We report a facile silica nanovehicle preparation procedure for hydrophobic drug delivery, which is carried out in water without adding any surfactant and additional catalyst. This strategy includes hydrophobic drug nanopaticle preparation by reprecipitation method and in situ hydrolyzation and polymerization to encapsulate this naoparticle using only N-(beta-amimoethyl)-gamma-aminopropyltriethoxysilane (AETPS). To demonstrate this technique hypocrellin A (HA), a hydrophobic photosensitizing anticancer drug, is embedded into silica nanovehicle using this simple method. The resulting HA encapsulated nanovehicles (HANV) are monodisperse and stable in aqueous solution. Comparative studies with free HA and entrapped HA have demonstrated that the encapsulation effect on the embedded photosensitizer nanoparticle significantly enhances the efficacy of singlet oxygen generation and, thereby, the in vitro photodynamic efficacy.

Citations

Apr 8, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Suhail Al-SalamAbdul-Kader Souid
May 6, 2014·Journal of Photochemistry and Photobiology. B, Biology·Lin ZhouJian Shen
Jan 21, 2014·International Journal of Biological Macromolecules·Mohammad Reza Saboktakin, Roya Mahdavi Tabatabaee
Sep 15, 2011·Chemistry : a European Journal·Lin ZhouJian Shen
Jul 22, 2010·Nanoscale·Pierre CouleaudJean-Olivier Durand
Feb 23, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Hanzhong KeWai-Kwok Wong
Jun 7, 2021·Colloids and Surfaces. B, Biointerfaces·Yixing LuGuanghui Zhao

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