A new staging system is more discriminant than conventional staging systems for unresectable hepatocellular carcinoma.

Journal of Cancer Research and Clinical Oncology
Bai-Hong ZhangChang-Quan Ling

Abstract

Prediction of the life expectancy of a patient with unresectable hepatocellular carcinoma (HCC) remains difficult. The aims of the study were to construct a new staging scheme for patients with unresectable HCC and to compare the discriminatory ability of the staging scheme with the Okuda and CLIP score and TNM staging system in a cohort of patients with unresectable HCC. A retrospective analysis of unresectable HCC cases from 1999 to 2003 was performed. The Cox model was used for multivariate analyses. The final model was derived from 10 randomly chosen training samples and the prognostic validity of the new staging scheme was assessed on the corresponding testing samples. Moreover, 54 cases with unresectable HCC were enrolled and prospectively followed up. The new staging, named the China integrated score (CIS), Okuda, TNM and CLIP systems were determined for each case. Comparisons of the survival rate between each stage were performed to evaluate their discriminatory ability. A simple scoring system was constructed, assigning linear scores (0/1/2) to the three covariates (TNM, alpha-fetoprotein and Child-Pugh) of the final model. The CIS system was more discriminant than the Okuda or TNM staging system, as confirmed by the K...Continue Reading

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Citations

Dec 10, 2015·Journal of Gastroenterology and Hepatology·Atsushi HiraokaHideki Kawasaki
Apr 8, 2015·World Journal of Hepatology·Akiyoshi KinoshitaHisao Tajiri
Aug 23, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Peter R GalleAndrew X Zhu
Jul 12, 2017·Oncology Letters·Zhan-Hong ChenRuihua Xu

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