A new strategy for septal ablation with transendocardial ethanol injection using a multifunctional intracardiac echocardiography catheter: a feasibility study in canines

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Rui GuoJing Huang


To evaluate the feasibility and safety of a novel multifunctional intracardiac echocardiography catheter for target septal ablation with transendocardial ethanol injection in canines. Percutaneous transluminal septal myocardial ablation has been the primary catheter-based strategy for the treatment of hypertrophic obstructive cardiomyopathy (HOCM). However, inherent limitations of the technique have reduced its therapeutic efficacy. A new catheter (10 F), integrated with a nitinol needle (29 G) and a 6.5-10-MHz, 32-element, side-fire ultrasound imaging transducer, was delivered into the right ventricle in nine canines and the left ventricle in three canines. A 0.3-ml microbubble and 0.5-1.5 ml absolute ethanol were sequentially injected into the interventricular septum. Electrocardiograph recordings were obtained during the whole procedure. Three hours after this operation, the heart was harvested for gross and histological examination. In all canines, the catheter provided the structural support and helped guide proper needle position within the septum. The microbubble further allowed the confirmation of the needle location through focal echo-density enhancement. Different amounts of ethanol infusion produced a dose-related ef...Continue Reading


Jun 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·J GasparJ Kuri
Feb 24, 2001·Cardiology in Review·Hubert SeggewissP Ziemssen
Nov 21, 2001·Current Controlled Trials in Cardiovascular Medicine·Hubert Seggewiss
Aug 3, 2002·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·David J CallansStephen M Dillon
Sep 3, 2004·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Lothar FaberDieter Horstkotte
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Josef VeselkaPavel Cervinka


Sep 8, 2012·Current Treatment Options in Cardiovascular Medicine·Sammy Elmariah, Michael A Fifer
Jul 26, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Carey Kimmelstiel
Sep 3, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Shvetank AgarwalHong Wang

Related Concepts

Canis familiaris
2D Echocardiography
Medical Device Design
Cardiac Catheterization Procedures
Ultrasonography, Intravascular
Ventricular Septum

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