A new strategy for septal ablation with transendocardial ethanol injection using a multifunctional intracardiac echocardiography catheter: a feasibility study in canines

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Rui GuoJing Huang

Abstract

To evaluate the feasibility and safety of a novel multifunctional intracardiac echocardiography catheter for target septal ablation with transendocardial ethanol injection in canines. Percutaneous transluminal septal myocardial ablation has been the primary catheter-based strategy for the treatment of hypertrophic obstructive cardiomyopathy (HOCM). However, inherent limitations of the technique have reduced its therapeutic efficacy. A new catheter (10 F), integrated with a nitinol needle (29 G) and a 6.5-10-MHz, 32-element, side-fire ultrasound imaging transducer, was delivered into the right ventricle in nine canines and the left ventricle in three canines. A 0.3-ml microbubble and 0.5-1.5 ml absolute ethanol were sequentially injected into the interventricular septum. Electrocardiograph recordings were obtained during the whole procedure. Three hours after this operation, the heart was harvested for gross and histological examination. In all canines, the catheter provided the structural support and helped guide proper needle position within the septum. The microbubble further allowed the confirmation of the needle location through focal echo-density enhancement. Different amounts of ethanol infusion produced a dose-related ef...Continue Reading

References

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Citations

Sep 8, 2012·Current Treatment Options in Cardiovascular Medicine·Sammy Elmariah, Michael A Fifer
Jul 26, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Carey Kimmelstiel
Sep 3, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Shvetank AgarwalHong Wang

Related Concepts

Ethanol
Canis familiaris
2D Echocardiography
Endocardium
Medical Device Design
Cardiac Catheterization Procedures
Injectables
Myocardium
Ultrasonography, Intravascular
Ventricular Septum

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