A new strategy for the early diagnosis of rheumatoid arthritis: a combined approach

Autoimmunity Reviews
A TedescoP Sabatini

Abstract

Rheumatoid arthritis [RA] is one of the most common and severe autoimmune rheumatic diseases, diagnosed primarily according to clinical manifestations and radiological reports. For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor [RF], as established by the ACR criteria. A recent test to detect antibodies towards citrullinated peptides, called the anti-CCP assay, showed a similar sensitivity but a more elevated specificity than the RF test. Our intention was the recognition of an optimal diagnostic strategy that exhibits the highest sensitivity and specificity for RA detection. To this purpose, we examine the usefulness of autoantibodies in RA testing, evaluating the diagnostic performance of conventional and innovative assays for RF detection, and ELISA anti-CCP test, for anti-CCP antibodies detection, by a prospective study. Multiplex cytofluorimetric test appeared to be more sensitive and specific than nephelometric assay for RF detection. Hence, a novel combined approach, significantly increasing the diagnostic sensitivity for RA, was planned, employing the multiplex RF test in combination with the anti-CCP test.

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Citations

Aug 30, 2011·Clinical Rheumatology·Siham Ali MetawiMaha Khalil Ibrahim
Aug 16, 2014·Biomarkers in Medicine·Anne S SiebuhrAnne C Bay-Jensen
Aug 19, 2010·Autoimmunity Reviews·Carlo Selmi
Nov 26, 2009·Autoimmunity Reviews·Karsten ConradThomas Dörner
Nov 10, 2009·Autoimmunity Reviews·Alan EbringerClyde Wilson
Aug 18, 2009·Autoimmunity Reviews·Francieli de Sousa RabeloAngélica Amorim Amato
Oct 4, 2014·Clinical Reviews in Allergy & Immunology·Shang-An ShuPatrick S C Leung
Sep 9, 2016·Zeitschrift für Rheumatologie·O ZenginA M Onat
May 1, 2011·Auto- Immunity Highlights·Jozélio Freire de CarvalhoYehuda Shoenfeld

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