PMID: 9541458Apr 16, 1998Paper

A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients

Immunology Letters
R CaudaW Malorni

Abstract

Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.

Citations

May 25, 2005·Fundamental & Clinical Pharmacology·Andrew OwenDavid J Back
Feb 9, 2011·Expert Opinion on Drug Metabolism & Toxicology·Neill James Liptrott, Andrew Owen
Feb 5, 2008·AIDS Research and Human Retroviruses·Marek J NowickiAlexandra M Levine
Apr 20, 2002·Current Opinion in Infectious Diseases·Patrick G Hoggard, David J Back
May 19, 2007·The Journal of Antimicrobial Chemotherapy·Leslie W ChinnDeanna L Kroetz

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