PMID: 9184823May 1, 1997Paper

A new substance (Yoshixol) with an interesting antibiotic mechanism from wood oil of Japanese traditional tree (Kiso-Hinoki), Chamaecyparis obtusa

General Pharmacology
S KoyamaJ Motoyoshiya

Abstract

1. A neutral wood oil was extracted from Chamaecyparis obtusa (Kiso-Hinoki), which has been trusted nationally and preserved historically in the central part of Japan (Kiso, Nagano). 2. Hinokitiol, or thujaplicin (C10H12O2), which has been believed to exist in Cupressaceae, was not found in this neutral wood oil. Some differences between the extracting processes of the natural products are discussed. 3. A new chemical substance (Yoshixol, 4,4-dimethyl-6-methylene-2-cyclohexen-1-one) was simulated by several criteria (details in the text) as a major candidate of the neutral wood oil from Chamaecyparis obtusa. Thus, Yoshixol was newly synthesized. 4. The antibiotic effects of hinokitiol, the neutral wood oil and Yoshixol on methicillin-resistant Staphylococcus aureus (MRSA) were examined bacteriologically and morphologically. 5. All of the aforementioned three test materials showed complete antibiotic effects on MRSA by the bacteriological examination. However, the morphological findings showed entirely different aspects of cell death. 6. Hinokitiol caused an aggregative, degenerative and/or necrotic aspect, but the neutral wood oil and Yoshixol produced characteristic aspects: separation of contacted cells, blebbing, bugging-lik...Continue Reading

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Citations

Jun 25, 2013·European Journal of Medicinal Chemistry·Sudipta GhoshLatha Rangan
Oct 2, 2003·Bioscience, Biotechnology, and Biochemistry·Hitoshi ShibataYoshihiro Sawa
May 20, 2003·Helicobacter·Tomoyuki OhnoJirO Imanishi
May 4, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vivek K BajpaiSun Chul Kang
Mar 2, 2006·Journal of the American Mosquito Control Association·Young-Su JangHoi-Seon Lee
Apr 18, 2012·International Journal of Immunopathology and Pharmacology·M-F ShihJ-Y Cherng

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