A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries.

World Journal of Surgery
Selman UranuesHorst Koch

Abstract

Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND. A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6-mm gap versus direct microsurgical suture repair without gap. We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect. This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host-donor differences in diameter, mismatches in number and pattern of fascicles, cross-sectional shape and area, and morbidity of the donor area.

References

Oct 1, 1985·Journal of Reconstructive Microsurgery·H Millesi
Apr 10, 2004·Neurological Research·Jason S BelkasRajiv Midha
Jun 16, 2005·Gait & Posture·Sebastian WolfRalf Mikut
Nov 1, 2005·Medical & Biological Engineering & Computing·H LanmüllerS Salmons
Aug 2, 2006·Muscle & Nerve·João Aris Kouyoumdjian
Nov 8, 2007·Acta Neurochirurgica. Supplement·H Millesi, R Schmidhammer
Aug 30, 2008·Injury·Elizabeth O Johnson, Panayotis N Soucacos
Jan 13, 2009·Hand : Official Journal of the American Association for Hand Surgery·Amy M MooreSusan E Mackinnon
Sep 23, 2009·Neurology India·Filiz EserCigdem Atan
Jan 5, 2011·The Journal of Hand Surgery·Susan E Mackinnon
Sep 25, 2012·Surgical Innovation·Selman UranüsHorst Koch
Sep 17, 2013·Cell Biochemistry and Biophysics·Ruijun LiLaijin Lu
Jan 5, 2014·European Surgery : ACA : Acta Chirurgica Austriaca·P J JohnsonS E Mackinnon

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Citations

Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Benedetta E FornasariStefania Raimondo

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