A new target for therapy in squamous cell carcinoma of the lung

Cancer Discovery
Kadoaki Ohashi, William Pao

Abstract

Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. Cellular, biochemical, and human data suggest that tumor cells harboring DDR2 mutations have increased sensitivity to existing tyrosine kinase inhibitors, providing rationale for clinical trials of agents that inhibit DDR2 kinase in the disease.

References

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May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hongbin JiKwok-Kin Wong
Nov 6, 2007·Nature·Barbara A WeirMatthew Meyerson
Sep 2, 2008·Cancer Research·Hiromasa YamamotoAdi F Gazdar
Jul 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D WilkersonD Neil Hayes
Sep 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Faye M JohnsonDavid J Stewart
Nov 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Corey J LangerJean-Charles Soria
Dec 3, 2010·The Journal of Pathology·William PaoZengliu Su

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