A new technique for the surgical creation of aneurysms in an in vivo tortuous vessel model to test neurovascular devices

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Jennifer ArendsElaine Lee

Abstract

The purpose of this study was to develop an aneurysm model that mimics the tortuous anatomy of the cerebrovasculature for the evaluation of endovascular devices. This model is an adaptation of the carotid siphon model of Georganos et al. The common carotid artery trunks in 10 swine were surgically elongated using an EXXCEL Soft ePTFE vascular graft and then sutured into position to form an S-curve, with each bend having a 5- to 10-mm radius. Following a 3- to 4-week healing period, aneurysms were surgically created from jugular vein grafts along or distal to the tortuous segment and immediately embolized with coils. In a subset (n = 6) of the arteries, a stent was also placed across the aneurysm neck. Animals were allowed to survive for 30 days. Clinical relevance and utility of the model were evaluated based on comparison to human angiographic images, physician feedback, and histopathological assessment. Tortuous anatomy was successfully created in all 10 animals, and aneurysms were added at various locations within or distal to the tortuous segment in a subset of 8 animals, creating 11 aneurysms in total. At 30 days, 18/20 vessels were patent and the bend radius was maintained. Endovascular access to aneurysms and placement o...Continue Reading

Citations

Feb 6, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Alexandra TrollopeJonathan Golledge
Dec 3, 2014·Journal of Biomechanics·Avione Y LeeHai-Chao Han
Feb 16, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Mohammadali SharzeheeHai-Chao Han
Jun 12, 2013·Revista do Colégio Brasileiro de Cirurgiões·Severino Lourenço da SilvaJoão Nicolle Tupiná Nogueira

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