A new technique to assess dermal absorption of volatile chemicals in vitro by thermal gravimetric analysis

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Matias RaumaG Johanson

Abstract

Potential health hazards of dermal exposure, variability in reported dermal absorption rates and potential losses from the skin by evaporation indicate a need for a simple, inexpensive and standardized procedure to measure dermal absorption and desorption of chemical substances. The aim of this study was to explore the possibility to measure dermal absorption and desorption of volatile chemicals using a new gravimetric technique, namely thermal gravimetric analysis (TGA), and trypsinated stratum corneum from pig. Changes in skin weight were readily detected before, during and after exposure to vapours of water, 2-propanol, methanol and toluene. The shape and height of the weight curves differed between the four chemicals, reflecting differences in diffusivity and partial pressure and skin:air partitioning, respectively. As the skin weight is highly sensitive to the partial pressure of volatile chemicals, including water, this technique requires carefully controlled conditions with respect to air flow, temperature, chemical vapour generation and humidity. This new technique may help in the assessment of dermal uptake of volatile chemicals. Only a small piece of skin is needed and skin integrity is not necessary, facilitating the...Continue Reading

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Citations

Apr 3, 2012·Advanced Drug Delivery Reviews·Matias RaumaGunnar Johanson
Feb 18, 2016·Journal of Pharmaceutical Sciences·Xin LiGerald B Kasting
Apr 22, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Matias Rauma, Gunnar Johanson
Jan 26, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Matias Rauma, Gunnar Johanson
Sep 28, 2018·Biometrical Journal. Biometrische Zeitschrift·Elvira M ErhardtMauro Gasparini

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