PMID: 9434293Jan 22, 1998Paper

A new technology for revascularization of cerebral embolism using liquid jet impact

Physics in Medicine and Biology
T KodamaH Uenohara

Abstract

Revascularization time is the dominant factor in the treatment of acute cerebral embolism. In this paper we describe a rapid revascularization therapy using liquid jets generated by the interaction of gas bubbles with shock waves, which impact on the thrombi. The interaction of a shock wave with a gas bubble attached to an artificial thrombus which was inserted into a tube model of a cerebral artery was investigated. The shock wave was generated by detonating a microexplosive pellet. The overpressure of the shock wave was 3.0 +/- 0.6 MPa (n = 7) and 12.7 +/- 0.4 MPa (n = 3). The initial air bubble radii were varied from 0.87 mm to 2.18 mm. The subsequent collapse of the bubble was photographed using a high-speed framing camera, and the liquid jet penetrating into the artificial thrombus was visualized using x-ray photography. The penetration depth of the liquid jet increased with increasing bubble size. There was an optimal separation distance between the bubble and the shock wave source to obtain the maximum penetration depth. Liquid jets have the potential to penetrate through thrombi in as little as a few microseconds, and with very efficient ablation.

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Citations

Sep 5, 2002·Lasers in Surgery and Medicine·Atsuhiro NakagawaTakashi Yoshimoto
Dec 18, 2001·Lasers in Surgery and Medicine·T HiranoT Yoshimoto
Sep 1, 2005·Journal of Thrombosis and Thrombolysis·Zoubeir HajriRéjean Fontaine
Aug 8, 1998·Ultrasound in Medicine & Biology·T Kodama, K Takayama
Jul 1, 1999·Ultrasound in Medicine & Biology·T KodamaK Takayama
Aug 26, 1999·Ultrasound in Medicine & Biology·T KodamaK Takayama
Feb 22, 2011·Journal of Neurotrauma·Atsuhiro NakagawaTeiji Tominaga
Dec 22, 2001·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·T HiranoT Yoshimoto

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