A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe

Free Radical Biology & Medicine
Mingqian TanJingli Yuan

Abstract

A terbium(III) chelate fluorescence probe for detection of singlet oxygen (1O2) in aqueous media, N,N,N1,N1-[2,6-bis(3'-aminomethyl-1'-pyrazolyl)-4-(9''-anthryl)pyridine] tetrakis (acetate)-Tb3+ (PATA-Tb3+), was designed and synthesized. The new chelate is highly water soluble, is almost nonfluorescent, and can specifically react with 1O2 to yield a strongly fluorescent chelate, the endoperoxide of PATA-Tb3+, accompanied by a remarkable increase in the fluorescence quantum yield from 0.46 to 10.5%. The long fluorescence lifetime of the endoperoxide (2.76 ms) allows the probe to be used favorably for time-resolved fluorescence detection of 1O2. The studies of fluorescence property and reaction specificity indicate that the new probe is highly sensitive and selective for 1O2. The probe was used for quantitative detection of 1O2 generated from a MoO4(2-) -H2O2 system to give a detection limit of 10.8 nM. In addition, the good applicability of the probe was demonstrated by the real-time monitoring of the kinetic process of 1O2 generation in a horseradish peroxidase-catalyzed oxidation system of indole-3-acetic acid in a weakly acidic buffer.

References

Jun 1, 1992·Photochemistry and Photobiology·J Moan, K Berg
Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Jan 1, 1988·Lasers in Surgery and Medicine·C J GomerA L Murphree
May 1, 1995·Pharmacology & Therapeutics·E F DicksonE P Diamandis
Mar 1, 1994·Photochemistry and Photobiology·A Michaeli, J Feitelson
Apr 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·A VillanuevaC Milanesi
Jun 26, 1998·Free Radical Biology & Medicine·S W Ryter, R M Tyrrell
Dec 14, 1999·Angewandte Chemie·N UmezawaT Nagano
Nov 7, 2002·The Journal of Biological Chemistry·Ken-ichi SetsukinaiTetsuo Nagano
Nov 30, 2002·Angewandte Chemie·Otto S WolfbeisZhihong Lin
May 15, 2003·Chemical Reviews·Claude Schweitzer, Reinhard Schmidt
May 24, 2003·Biochemical and Biophysical Research Communications·Michael J Davies
Jul 10, 2003·Journal of the American Chemical Society·Tetsuo MiuraShunichi Fukuzumi
Apr 30, 2005·Analytical Chemistry·Laura A MacManus-SpencerKristopher McNeill
May 14, 2005·Free Radical Biology & Medicine·Glaucia R MartinezPaolo Di Mascio
Jun 23, 2005·Journal of the American Chemical Society·Laura A MacManus-Spencer, Kristopher McNeill
Jul 13, 2005·Chemical Communications : Chem Comm·Bo SongJingli Yuan

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Citations

Jan 18, 2007·Analytical and Bioanalytical Chemistry·David CostaJosé L F C Lima
Mar 9, 2013·Journal of Fluorescence·Eliana F C SimõesJoaquim C G Esteves da Silva
Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li
Aug 11, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ana F T SilvaJosé L F C Lima
Mar 14, 2009·Analytical and Bioanalytical Chemistry·Aurore Thibon, Valérie C Pierre
May 21, 2010·Chemistry : a European Journal·Cuihong SongYafeng Guan
Jun 2, 2011·Chemical Society Reviews·Xiaoqiang ChenJuyoung Yoon
Feb 24, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Hong-Ju YinKe-Zhi Wang
May 3, 2018·Organic & Biomolecular Chemistry·Youngmin You
Sep 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhiqiang YeJingli Yuan
Feb 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhichao DaiJingli Yuan
Jun 24, 2020·Accounts of Chemical Research·Run Zhang, Jingli Yuan

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