A new theory of phylogeny inference through construction of multidimensional vector space

Molecular Biology and Evolution
Yasuhiro KitazoeT Suzuki

Abstract

Here, a new theory of molecular phylogeny is developed in a multidimensional vector space (MVS). The molecular evolution is represented as a successive splitting of branch vectors in the MVS. The end points of these vectors are the extant species and indicate the specific directions reflected by their individual histories of evolution in the past. This representation makes it possible to infer the phylogeny (evolutionary histories) from the spatial positions of the end points. Search vectors are introduced to draw out the groups of species distributed around them. These groups are classified according to the nearby order of branches with them. A law of physics is applied to determine the species positions in the MVS. The species are regarded as the particles moving in time according to the equation of motion, finally falling into the lowest-energy state in spite of their randomly distributed initial condition. This falling into the ground state results in the construction of an MVS in which the relative distances between two particles are equal to the substitution distances. The species positions are obtained prior to the phylogeny inference. Therefore, as the number of species increases, the species vectors can be more specifi...Continue Reading

References

Mar 12, 1992·Nature·M J Novacek
Jun 1, 1992·Computer Applications in the Biosciences : CABIOS·D T JonesJ M Thornton
Dec 1, 1967·Science·V M Sarich, A C Wilson
Jan 20, 1967·Science·W M Fitch, E Margoliash
Jan 10, 1981·Nucleic Acids Research·R GranthamR Mercier
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·S B Hedges
Feb 1, 1996·Journal of Molecular Evolution·A JankeS Pääbo
Jul 3, 1997·Nature·M S SpringerM J Stanhope
May 15, 1998·Nature·S Kumar, S B Hedges
Oct 10, 1998·Journal of Molecular Evolution·T A GorrT Kleinschmidt
Oct 1, 1988·Physical Review C: Nuclear Physics·D H Boal, J N Glosli
Feb 12, 1999·Science·S B Hedges, L L Poling

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