A new tissue segmentation method to calculate 3D dose in small animal radiation therapy

Radiation Oncology
C NobletS Chiavassa

Abstract

In pre-clinical animal experiments, radiation delivery is usually delivered with kV photon beams, in contrast to the MV beams used in clinical irradiation, because of the small size of the animals. At this medium energy range, however, the contribution of the photoelectric effect to absorbed dose is significant. Accurate dose calculation therefore requires a more detailed tissue definition because both density (ρ) and elemental composition (Zeff) affect the dose distribution. Moreover, when applied to cone beam CT (CBCT) acquisitions, the stoichiometric calibration of HU becomes inefficient as it is designed for highly collimated fan beam CT acquisitions. In this study, we propose an automatic tissue segmentation method of CBCT imaging that assigns both density (ρ) and elemental composition (Zeff) in small animal dose calculation. The method is based on the relationship found between CBCT number and ρ*Zeff product computed from known materials. Monte Carlo calculations were performed to evaluate the impact of ρZeff variation on the absorbed dose in tissues. These results led to the creation of a tissue database composed of artificial tissues interpolated from tissue values published by the ICRU. The ρZeff method was validated b...Continue Reading

References

Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Jun 3, 1998·Medical Physics·D A LowJ A Purdy
Mar 31, 2005·Physics in Medicine and Biology·Frank Verhaegen, Slobodan Devic
Jan 18, 2007·Physics in Medicine and Biology·Barbara VanderstraetenHubert Thierens
Apr 22, 2009·Medical Physics·Hu ZhouEdward E Graves
May 28, 2011·Physics in Medicine and Biology·Frank VerhaegenErik Tryggestad
Jul 23, 2011·Medical Physics·Andre MickeXiang Yu
Aug 6, 2011·Medical Physics·Magdalena Bazalova, Edward E Graves
Jun 19, 2012·Physics in Medicine and Biology·Stefan J van HoofFrank Verhaegen
Nov 22, 2017·Radiation Oncology·Ana VaniquiFrank Verhaegen

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