A new total hemiface allotransplantation model in rats

Microsurgery
Yalcin KulahciMaria Siemionow

Abstract

Vascularized composite allotransplantation (VCA), a new reconstructive option for patients suffering from extensive facial defects leads to superior functional and aesthetic outcomes compared to the standard autologous reconstruction. Among VCA recipients, each case involves different facial structures and tissues depending on the patient's injury, thus drawing conclusions on the mechanism of immune interactions between the donor and recipient is challenging. This study introduces a new total hemiface VCA model, including scalp, external ear, mystacial pad, premaxilla, upper/lower lids, nose, and upper/lower lips to evaluate the effect of transplantation of multitissue VCA on the recipient's immune response. Ten hemiface allotransplantations were performed in two groups between Lewis-Lewis (isograft) and LBN-Lewis (allograft) rats. Cyclosporine A (CsA) monotherapy was applied in the allograft group to prevent rejection. All flaps survived up to 100 days post-transplant. The mean warm ischemia time was 45 minutes. Histological analysis revealed normal bone, cartilage (ear and nose), conjunctiva, palpebra, and eyelashes. Flow cytometry confirmed donor-specific chimerism for T cells (CD4/RT1(n) and CD8/RT1(n)) and B cells (CD45RA/...Continue Reading

References

Oct 1, 1976·Plastic and Reconstructive Surgery·O O Erol
Mar 1, 1991·Plastic and Reconstructive Surgery·W P LeeA J Weiland
Oct 1, 1983·British Journal of Plastic Surgery·A H McIndoe
Dec 1, 1994·Plastic and Reconstructive Surgery·T KawashimaK Harii
Mar 17, 1999·Plastic and Reconstructive Surgery·O LatifoğluK Atabay
Jun 7, 2003·Transplantation·Maria SiemionowJames E Zins
Sep 25, 2003·Plastic and Reconstructive Surgery·Betul G UlusalMaria Z Siemionow
Dec 4, 2004·Plastic and Reconstructive Surgery·Yavuz DemirMaria Siemionow
Dec 24, 2005·Annals of Plastic Surgery·Luis Landin, Pedro C Cavadas
Jul 18, 2006·Lancet·Bernard DevauchelleJean-Michel Dubernard
Oct 20, 2006·Plastic and Reconstructive Surgery·Ilker YaziciMaria Siemionow
May 2, 2007·Annals of Plastic Surgery·Ilker YaziciMaria Siemionow
Jun 27, 2008·Annals of Plastic Surgery·Ilker YaziciMaria Siemionow
Jul 16, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Luis LandinAraceli Caballero
Oct 25, 2008·Annals of Plastic Surgery·Serdar NasirMaria Siemionow
Aug 19, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Serdar NasirMaria Siemionow
Sep 12, 2009·Annals of Plastic Surgery·Luis LandinJose C Rodriguez-Perez
Sep 23, 2009·Plastic and Reconstructive Surgery·Maria Z SiemionowJohn Fung
Jan 9, 2010·Plastic and Reconstructive Surgery·Maria Z SiemionowMehmet Bozkurt
Dec 22, 2009·Annals of Plastic Surgery·Yalcin Kulahci, Maria Siemionow
Dec 24, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Fatih ZorMaria Siemionow
Nov 1, 2007·Seminars in Plastic Surgery·Maria Siemionow, Yalcin Kulahci
Jan 14, 2011·Plastic and Reconstructive Surgery·Jean-Paul MeningaudLaurent Lantieri
Aug 13, 2011·Annals of Plastic Surgery·Chad R GordonW P Andrew Lee
Nov 19, 2011·Plastic and Reconstructive Surgery·Maria Siemionow, Can Ozturk
May 28, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Alejandro E RamirezFu-Chan Wei

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