A new transglutaminase-like from the ascidian Ciona intestinalis

FEBS Letters
L CarielloL Zanetti

Abstract

A cDNA clone encoding a transglutaminase (TGase) was isolated from a cDNA library prepared from the larval stage of Ciona intestinalis. The cDNA sequence has an open reading frame encoding a protein of 696 amino acids and is about 36% identical to 11 other TGase sequences. In addition, the critical residues thought to form the catalytic center are conserved. The Ciona TGase (CiTGase) has an extension of 39 amino acids in the NH2-terminal region similar to that reported for keratinocyte TGases. A phylogenetic analysis among other types of TGases demonstrated that CiTGase represents a new type of the enzyme.

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Citations

Feb 27, 2003·Biochemical and Biophysical Research Communications·Kazuhito ShidaAtsuo Kasuya
Oct 2, 2002·Gene·Giuliana de Luca di RosetoGiorgio Bernardi
Aug 19, 1999·Protein Science : a Publication of the Protein Society·K S MakarovaE V Koonin
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·S N Prasanna MurthyLaszlo Lorand
Jun 18, 2015·Journal of Thrombosis and Haemostasis : JTH·H HandrkovaH P Kohler
Sep 24, 2004·The Journal of Biological Chemistry·Laura ZanettiLucio Cariello

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