A new transmissible viral hepatitis of marmosets and tamarins

The Journal of Infectious Diseases
R J MontaliK V Holmes

Abstract

Callitrichid hepatitis (CH) is a newly recognized, acute, fatal, epizootic disease of New World primates in the family Callitrichidae. Since 1980, 12 outbreaks of CH have occurred in US zoos, involving several callitrichid species including the endangered golden lion tamarin (Leontopithecus rosalia). CH was experimentally transmitted to common marmosets via a bacteria-free filtrate of liver from a naturally infected tamarin. All three inoculated marmosets developed an acute fatal disease with the characteristic clinical and histopathologic findings of CH. Human hepatotropic viruses that can infect the livers of callitrichids were not detected serologically in any of the experimentally infected marmosets. Enveloped viruslike particles 85-105 nm in diameter were observed in the rough endoplasmic reticulum and Golgi complex of hepatocytes from both naturally infected and experimentally inoculated animals. An immunoblot assay was developed using sera from tamarins exposed to natural outbreaks of CH and liver extracts from experimentally infected or control marmosets. A new CH-specific antigen was detected in the livers of naturally infected and experimentally inoculated marmosets but not controls. These results suggest that the eti...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
J P SundbergD L Adkison
© 2022 Meta ULC. All rights reserved