PMID: 2941177Jan 1, 1986Paper

A new triphenylethylene compound, Fc-1157a. II. Antitumor effects

Cancer Chemotherapy and Pharmacology
L KangasR Toivola

Abstract

The antitumor effects of a new antiestrogen, Fc-1157a have been studied in vitro and in vivo. In vitro the effect of Fc-1157a was comparable to that of tamoxifen. The effect was dose-dependent, and at concentrations higher than 10(-6) mol/1 Fc-1157a induced real cell death of the MCF-7 cells. In DMBA-induced mammary cancer in rats Fc-1157a decreased the number of new tumors and inhibited the growth of existing tumors, these effects being statistically highly significant. The ratio of growing tumors to stable and regressing tumors was significantly decreased. Although these effects were slightly stronger with Fc-1157a than with tamoxifen, the difference between these two compounds was not statistically significant. Murine uterine sarcoma, an estrogen receptor-negative tumor, was resistant to tamoxifen, but was statistically significantly inhibited by high doses (100 and 200 mg/kg-1 day-1 for 5 days) of Fc-1157a. The antitumor effects of Fc-1157a are due mainly to the antiestrogenic activity. At high concentrations in vitro and at high doses in vivo Fc-1157a exerts antitumor effects some of which are different from those of tamoxifen and are directed even against estrogen receptor-negative tumors. The exact mechanism of the obser...Continue Reading

References

Nov 1, 1973·Journal of the National Cancer Institute·H D SouleM Brennan
May 1, 1984·British Journal of Obstetrics and Gynaecology·M GrönroosR Johansson
Mar 1, 1983·European Journal of Cancer & Clinical Oncology·R L SutherlandM D Green
Jan 1, 1984·Journal of Steroid Biochemistry·H RochefortF Vignon
Aug 4, 1984·British Medical Journal·A M BlackburnR D Rubens
Jan 1, 1984·Journal of Steroid Biochemistry·G SicaS Iacobelli
Feb 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V C Jordan, K E Allen
Feb 1, 1983·Annals of Internal Medicine·D C TormeyJ G Cassidy
Aug 1, 1983·Endocrinology·S M SchollM E Lippman

Citations

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·L Kangas
Aug 1, 1990·Breast Cancer Research and Treatment·P C KohlerD C Tormey
Aug 1, 1990·Breast Cancer Research and Treatment·T TominagaY Nomura
Aug 1, 1990·Breast Cancer Research and Treatment·R Valavaara
Jan 2, 1994·International Journal of Cancer. Journal International Du Cancer·K PyykköM Lähde
Jan 1, 1993·Breast Cancer Research and Treatment·L E StenbygaardP Dombernowsky
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kaija HolliH Joensuu
Dec 14, 2004·Cancer Chemotherapy and Pharmacology·Mika WallénJ U Mäenpää
Nov 13, 2004·Breast Cancer Research and Treatment·Mikihiro KusamaH Doihara
Jan 25, 2005·Cancer Biotherapy & Radiopharmaceuticals·Zoltán MarcsekAnna Tompa
Sep 13, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Morihiko KimuraNobuoki Eshima
Aug 24, 2012·International Journal of Cancer. Journal International Du Cancer·Juhyun KimJames T Dalton
Jun 18, 2020·International Journal of Molecular Sciences·Divya BafnaArtem Cherkasov
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·L KangasJ Tuominen
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·R ValavaaraA Toivanen
Aug 1, 1990·Breast Cancer Research and Treatment·L Kangas
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H MinnH Sipilä
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C K OsborneS A Fuqua
Dec 25, 2003·Breast Cancer Research and Treatment·J EllménD M Hayes
Aug 1, 1990·Breast Cancer Research and Treatment·S Pyrhönen
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·T VuorioE Vuorio
Jul 1, 1988·Pharmacology & Toxicology·H SipiläT Halme
Jan 1, 1990·Cancer Investigation·V C Jordan
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·J U MäenpääM W DeGregorio
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Nanna SarvilinnaTimo Ylikomi
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Chen MaoJin Ling Tang
Jan 1, 1990·Cancer Investigation·J T Hamm
Jan 1, 1992·Acta Oncologica·H HaarstadS Kvinnsland
Jan 1, 1994·Breast Cancer Research and Treatment·S PyrhönenA Hajba
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·R GrenmanH Joensuu
Oct 21, 1991·International Journal of Cancer. Journal International Du Cancer·A M WärriP L Härkönen
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·R L HuovinenY U Collan
Jun 14, 2000·Breast Cancer Research and Treatment·R S Rosenberg ZandE P Diamandis
Jul 1, 1998·The Breast Journal·N K Ibrahim, G N Hortobagyi
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·S E Minton
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·L WebsterJ Bishop
Aug 1, 1990·Breast Cancer Research and Treatment·S P RobinsonV C Jordan
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·V J WiebeM W DeGregorio
Jun 1, 1997·Molecular Aspects of Medicine·V C Jordan, W J Gradishar
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M WärriP L Härkönen

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