A new triterpene From Uncaria macrophylla and its antitumor activity.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Guangli SunJingquan Yuan

Abstract

On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL.

References

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Jun 9, 1999·Bioorganic & Medicinal Chemistry Letters·J S LeeJ S Ahn
Jan 12, 2000·Planta medica·K K LeeG B Hammond
Jan 10, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangli SunJingquan Yuan
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Citations

Jun 21, 2015·Journal of Ethnopharmacology·Qian ZhangWei Qu
Feb 4, 2014·Natural Product Research·Mingliang ZhongXudong Xu
Jan 29, 2021·Journal of Asian Natural Products Research·Ruo-Fei LiJian-Gong Shi
Nov 6, 2021·Natural Product Research·Xin-Xin LiangXiao-Li Li

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Methods Mentioned

BETA
NMR

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