PMID: 9171402Jun 1, 1997Paper

A new type of hemophore-dependent heme acquisition system of Serratia marcescens reconstituted in Escherichia coli

Journal of Bacteriology
J M GhigoC Wandersman

Abstract

The utilization by Serratia marcescens of heme bound to hemoglobin requires HasA, an extracellular heme-binding protein. This unique heme acquisition system was studied in an Escherichia coli hemA mutant that was a heme auxotroph. We identified a 92-kDa iron-regulated S. marcescens outer membrane protein, HasR, which alone enabled the E. coli hemA mutant to grow on heme or hemoglobin as a porphyrin source. The concomitant secretion of HasA by the HasR-producing hemA mutant greatly facilitates the acquisition of heme from hemoglobin. This is the first report of a synergy between an outer membrane protein and an extracellular heme-binding protein, HasA, acting as a heme carrier, which we termed a hemophore.

References

Nov 16, 1992·Science·H Nikaido, M H Saier
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M L SmithK G Paul
Jan 1, 1981·Annual Review of Biochemistry·J B Neilands
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·S LétofféC Wandersman
Sep 1, 1994·Journal of Bacteriology·S LétofféC Wandersman
May 1, 1996·Trends in Microbiology·S D Gray-Owen, A B Schryvers
Nov 1, 1995·Molecular Microbiology·B C Lee

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Citations

Nov 28, 2001·Molecular Microbiology·A R Mey, S M Payne
Dec 29, 2007·The Journal of Biological Chemistry·Célia Caillet-SaguyAnne Lecroisey
Feb 1, 2011·Molecular Microbiology·Clémence FournierPhilippe Delepelaire
Jun 22, 2012·Molecular Microbiology·Cécile Wandersman, Philippe Delepelaire
Jun 16, 2012·The Journal of Biological Chemistry·Célia Caillet-SaguyAnne Lecroisey
Apr 21, 2017·Annual Review of Biochemistry·Weiliang Huang, Angela Wilks
Jun 1, 2001·The Journal of Biological Chemistry·Q Ren, L Thony-Meyer
Aug 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sylvie LétofféCécile Wandersman
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KriegWolfram Welte
Dec 4, 2010·The Biochemical Journal·Areli Cruz-CastañedaJosé J Olivares-Trejo
Jul 10, 2013·Infection and Immunity·Nermi L ParrowMichael F Minnick
Feb 24, 2015·Immunological Reviews·Olivier NeyrollesMichael Niederweis
May 21, 2016·Frontiers in Cellular and Infection Microbiology·María E Romero-EspejelJosé de Jesús Olivares-Trejo
Dec 17, 2016·Genes·Alexandria A Reinhart, Amanda G Oglesby-Sherrouse
Sep 5, 2001·Molecular Microbiology·A NienaberH M Fischer
Oct 19, 2004·Annual Review of Microbiology·Cécile Wandersman, Philippe Delepelaire
Jan 18, 2005·FEMS Microbiology Reviews·Teresa OlczakCaroline Attardo Genco
Oct 2, 2004·Molecular Microbiology·Isabelle J SchalkSusan K Buchanan
Feb 3, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S CescauF Biville
May 27, 2005·Archives of Microbiology·Sandra Juíz RíoManuel L Lemos
Jan 12, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Elizabeth E WyckoffShelley M Payne
Dec 19, 2018·ELife·Sandra Breum AndersenAshleigh S Griffin
Apr 24, 1999·European Journal of Biochemistry·N Izadi-PruneyreA Lecroisey
Oct 6, 2000·Annual Review of Microbiology·C Ratledge, L G Dover
Jun 28, 2003·The Journal of Biological Chemistry·Nicolas WolffPhilippe Delepelaire
Oct 27, 2015·Metallomics : Integrated Biometal Science·Li MaAnthony W Maresso

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