A new type of stochastic dependence revealed in gene expression data

Statistical Applications in Genetics and Molecular Biology
Lev KlebanovAndrei Yakovlev

Abstract

Modern methods of microarray data analysis are biased towards selecting those genes that display the most pronounced differential expression. The magnitude of differential expression does not necessarily indicate biological significance and other criteria are needed to supplement the information on differential expression. Three large sets of microarray data on childhood leukemia were analyzed by an original method introduced in this paper. A new type of stochastic dependence between expression levels in gene pairs was deciphered by our analysis. This modulation-like unidirectional dependence between expression signals arises when the expression of a "gene-modulator'' is stochastically proportional to that of a "gene-driver''. A total of more than 35% of all pairs formed from 12550 genes were conservatively estimated to belong to this type. There are genes that tend to form Type A relationships with the overwhelming majority of genes. However, this picture is not static: the composition of Type A gene pairs may undergo dramatic changes when comparing two phenotypes. The ability to identify genes that act as ;;modulators'' provides a potential strategy of prioritizing candidate genes.

Citations

Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Anthony AlmudevarAndrei Y Yakovlev
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey T Leek, John D Storey
Sep 23, 2011·BMC Bioinformatics·Mark NeedhamXing Qiu
Mar 1, 2013·BMC Bioinformatics·Erik KristianssonOlle Nerman
Oct 7, 2008·BMC Bioinformatics·Zhenqiu LiuXiaoli Jiao
Oct 20, 2010·BMC Genomics·Daniel M GattiFred A Wright
Jun 29, 2007·Bioinformation·Lev Klebanov, Andrei Yakovlev
Nov 19, 2008·Journal of Theoretical Biology·Leonid HaninAndrei Yakovlev
Jun 28, 2011·Computational Biology and Chemistry·Dong WangZheng Guo
Aug 3, 2006·Bioinformatics·Anbupalam ThalamuthuGeorge C Tseng

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