PMID: 2125286Dec 1, 1990Paper

A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs

Genes & Development
T Hartshorne, N Agabian

Abstract

A new model of U2 RNA secondary structure has been developed by comparing U2 RNA sequences from distantly related trypanosomatids, which process their RNAs by trans-splicing, and U2 RNAs from cis-splicing organisms. The trypanosomatid U2 RNA retains structural similarity in important functional domains of cis-splicing U2 RNAs yet differs from previous consensus models in that only two helices, rather than three, can form in the stem-loop II region. This alteration eliminates the capacity for pseudoknot formation and produces a single-stranded region 3' to stem-loop II, which may be accessible for snRNP protein binding. Trypanosomatid U2 RNAs differ in the putative branchpoint recognition sequences, which completely diverge from the conserved GUAGUA consensus of cis-splicing organisms.

Citations

Feb 15, 1991·Experientia·K Perry, N Agabian
Mar 1, 1992·Molecular and Biochemical Parasitology·S MichaeliE Ullu
Jul 1, 1995·Molecular and Biochemical Parasitology·T W Nilsen
Jun 1, 2005·Molecular and Biochemical Parasitology·Stephan LückeAlbrecht Bindereif
Feb 13, 2001·Molecular and Biochemical Parasitology·P XuG A Buck
Dec 2, 1996·Molecular and Biochemical Parasitology·S Metzenberg, N Agabian
Sep 11, 1991·Nucleic Acids Research
Aug 25, 1994·Nucleic Acids Research·T Hartshorne, N Agabian
Oct 14, 2003·Eukaryotic Cell·Xue-hai LiangShulamit Michaeli
Oct 13, 2005·Molecular and Biochemical Parasitology·Xue-hai LiangShulamit Michaeli
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Nov 1, 1992·Molecular and Cellular Biology·K P McNally, N Agabian
Oct 1, 1991·Genes & Development·K P Watkins, N Agabian

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