A new variant translocation of t(15;17) in a patient with acute promyelocytic leukemia (M3): t(15;19;17)(q22;p13;q12)

Cancer Genetics and Cytogenetics
K SaitohA B Miura

Abstract

The reciprocal translocation (15;17) is specifically associated with acute promyelocytic leukemia [APL; M3 subtype according to French-American-British (FAB) classification]. A few patients with this disease have complex variant translocations. We describe a patient with M3 carrying t(15;19;17)(q22;p13;q12), which is a new type of variant translocation. The karyotypic interpretation was confirmed by Southern blot analysis with the use of RAR alpha and by fluorescence in situ hybridization (FISH) with the use of painting probes of chromosomes 15, 17, and 19 and a (15;17) translocation DNA probe. The results support the idea that the key event in APL is the formation of fusion gene PML/RAR alpha on the der(15).

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Citations

Feb 5, 2009·International Journal of Hematology·Takayasu KatoMineo Kurokawa
Jan 21, 2011·Indian Journal of Cancer·S PolampalliS Banavali
May 15, 2007·Cancer Genetics and Cytogenetics·Gudrun GöhringB Schlegelberger
Jun 2, 2006·Cancer Genetics and Cytogenetics·Soo Jin YooJeong-Yeal Ahn
Jun 19, 2008·Cancer Genetics and Cytogenetics·Shori AbeTomohiro Sugawara

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