A new view of integrin αIIbβ3 bound to membrane.

Blood
Jun Qin, Edward F Plow

Abstract

In this issue of Blood, Choi et al report a 3-dimensional (3D) reconstruction model of integrin aIIbb3 in its latent state which challenges the existing paradigm and provides new insights into the mechanism of integrin activation.

References

Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian D Adair, Mark Yeager
Feb 4, 2006·Molecular Cell·Tiila KiemaDavid A Calderwood
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jun YangJun Qin
Dec 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Douglas G MetcalfWilliam F DeGrado
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Iain D Campbell, Martin J Humphries
May 31, 2013·Nature Reviews. Molecular Cell Biology·Daniel BouvardJohanna Ivaska
Jul 4, 2013·Nature Reviews. Molecular Cell Biology·Alison Schuldt

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Citations

Apr 1, 2015·British Journal of Haematology·Anders ÖsterborgMartin J S Dyer

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