A New Vision for Therapeutic Hypothermia in the Era of Targeted Temperature Management: A Speculative Synthesis

Therapeutic Hypothermia and Temperature Management
Travis C Jackson, Patrick M Kochanek

Abstract

Three decades of animal studies have reproducibly shown that hypothermia is profoundly cerebroprotective during or after a central nervous system (CNS) insult. The success of hypothermia in preclinical acute brain injury has not only fostered continued interest in research on the classic secondary injury mechanisms that are prevented or blunted by hypothermia but has also sparked a surge of new interest in elucidating beneficial signaling molecules that are increased by cooling. Ironically, while research into cold-induced neuroprotection is enjoying newfound interest in chronic neurodegenerative disease, conversely, the scope of the utility of therapeutic hypothermia (TH) across the field of acute brain injury is somewhat controversial and remains to be fully defined. This has led to the era of Targeted Temperature Management, which emphasizes a wider range of temperatures (33-36°C) showing benefit in acute brain injury. In this comprehensive review, we focus on our current understandings of the novel neuroprotective mechanisms activated by TH, and discuss the critical importance of developmental age germane to its clinical efficacy. We review emerging data on four cold stress hormones and three cold shock proteins that have g...Continue Reading

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Citations

May 29, 2019·Therapeutic Hypothermia and Temperature Management·Peter AndrewsTravis C Jackson
Oct 1, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Travis C JacksonPatrick M Kochanek
May 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Melika HosseiniYama Akbari
Apr 8, 2020·BioResearch Open Access·Walter H MoosXiaohong Chen
Jan 8, 2021·Molecular Neurobiology·Travis C JacksonPatrick M Kochanek
Jan 18, 2021·Experimental Gerontology·Joanna RymaszewskaDorota Szcześniak
Feb 23, 2021·Therapeutic Hypothermia and Temperature Management·Sophie C RosahlEmmanuel Urquieta
Mar 5, 2021·Resuscitation·Patrick J Coppler, Jonathan Elmer
Mar 20, 2021·Journal of Neuro-oncology·Clémentine FulbertDavid Ratel
May 22, 2021·Journal of Thermal Biology·Nadezhda M ZakharovaAnatoly L Kovtun
Mar 1, 2020·Current Treatment Options in Neurology·Benjamin E ZusmanRuchira M Jha
Jul 17, 2021·Circulation. Cardiovascular Interventions·Mohamed El FarissiLuuk C Otterspoor
Jul 15, 2021·Critical Care Medicine·Heidi J DaltonRobert H Bartlett
Aug 27, 2021·Resuscitation·Patrick J Coppler, Jonathan Elmer

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Methods Mentioned

BETA
transgenic
enzyme-linked immunosorbent assay
ELISAs
ELISA
environmental cold stress
Chip
flow cytometry
lateral

Clinical Trials Mentioned

NCT01042015

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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