A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling

Histopathology
C MarchiòG Bussolati

Abstract

To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast. We studied a series of 20 pure TC and 22 TLC, evaluating the architectural features of the two entities by bi-dimensional microscopy and by 3-D modelling. We traced the spatial organization of three TCs and three TLCs on serial sections using AE1/AE3 cytokeratin as a marker of the epithelial structures and reconstructed 3-D models of each histological type. The analysis of TC on serial cytokeratin-stained sections showed that the form of the 'tubules' was related to the plane of sectioning and that often they were tear-drop shaped, with a final tail of single cells connecting them together. 3-D models corresponded to a necklace appearance and the tubules of TC appeared as blebs bridging through solid cords to other blebs. In TLC the structure was similar, but the connecting single-cell files were usually longer. Both TC and TLC showed similar E-cadherin positivity and an indolent clinical behaviour. TC and TLC share the same architectural and growth patterns and ultimately seem to represent variants of the same tumour type.

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Citations

Jan 18, 2014·Der Pathologe·H-P SinnS Aulmann
Jan 4, 2008·Histopathology·A M Hanby, T A Hughes
Aug 19, 2006·European Journal of Radiology·Işil Günhan-Bilgen, Ayşenur Oktay
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