PMID: 2502594May 1, 1989Paper

A new way to induce oestrogen-deficiency osteopaenia in the rat: comparison of the effects of surgical ovariectomy and administration of the LHRH agonist buserelin on bone resorption and composition

The Journal of Endocrinology
A Goulding, E Gold

Abstract

Prolonged administration of LHRH agonist suppresses pituitary gonadotrophin secretion, thereby lowering blood oestrogen. This study was undertaken to compare the osteopaenic effects of bilateral ovariectomy and chronic administration of the LHRH agonist, buserelin, in the rat. Four groups of animals which had their skeletons labelled with 45Ca were studied for 4 weeks. Group 1 underwent a sham-ovariectomy, group 2 were surgically ovariectomized, group 3 were given buserelin by daily s.c. injection and group 4 were given a continuous infusion of buserelin by osmotic minipump. Plasma concentrations of oestradiol were measured weekly. Bone resorption was assessed by measuring the urinary excretion of 45Ca and hydroxyproline and determining bone 45Ca content. Ovariectomy and buserelin treatments lowered blood oestradiol, increased biochemical indices of bone resorption and decreased femur and total body calcium and 45Ca values. The degree of oesteopaenia elicited by ovariectomy and buserelin treatment was similar. Bone responses to s.c. buserelin and to continuous buserelin infusion were alike. We attribute evidence of increases in bone resorption and induction of osteopaenia with buserelin treatment to hypo-oestrogenism. We have s...Continue Reading

Citations

Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, L Fisher
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, E Gold
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J H TobiasA Gallagher
Apr 1, 1994·Calcified Tissue International·M P CollinsonC Hutton
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·L P Schot, A H Schuurs
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K C WesterlindR T Turner
Sep 11, 2018·International Journal of Endocrinology and Metabolism·Putri Ayu JayusmanAhmad Nazrun Shuid
Feb 4, 2003·Journal of Pineal Research·Marta G LadizeskyDaniel P Cardinali
Feb 4, 2003·Journal of Pineal Research·Daniel P CardinaliCarlos Mautalen
Jan 1, 2014·BoneKEy Reports·Antonia Sophocleous, Aymen I Idris
Mar 3, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Nur-Vaizura MohamadKok-Yong Chin

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