PMID: 591105Jan 1, 1977

A new well-characterized, purified allergen preparation from timothy pollen. III. Immunological properties in the human immunoglobulin E system

International Archives of Allergy and Applied Immunology
O GrimmerK Aas


The following methods were used in vitro to characterize and quantitate the allergenic activity of a purified allergen preparation, Timothy N, from timothy pollen: radioallergosorbent test (RAST), direct-titration RAST and RAST inhibition. Vials containing freeze-dried and standardized quantities of this preparation showed good uniformity and accuracy with regard to the allergenic activity. The stability of the preparation in solution and in the freeze-dried state was tested by RAST inhibition and was found to be acceptable. Using the same method, the allergenic activity of Timothy N was compared to the allergenic activity of a crude extract, Timothy O, indicating a discrepancy which was not observed in vivo.

Related Concepts

Drug Stability
Freeze Drying
Immunoglobulin E
Male Gametophytes
Radioallergosorbent Test

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