PMID: 8601721Feb 1, 1996Paper

A new wound healing agent--sphingosylphosphorylcholine

The Journal of Investigative Dermatology
L SunT B Nielsen

Abstract

Spingosylphosphorylcholine (lysosphingomyelin or SPC) is an effective and broad spectrum cell growth promoting agent and a candidate for evaluation on wound healing. The effect of SPC on full-thickness excision and incision wounds in genetically healing-impaired diabetic (db/db) mice was evaluated by measurement of wound area, skin strength, and tissue histology. The effect on cell proliferation was measured in vivo by incorporation of bromo-deoxyuridine and in vitro by [3H] thymidine incorporation. SPC increased the rate of wound closure, with a statistically significant improvement in measured wound areas (p < 0.02, compared with vehicle controls). The optimum concentration was 2-3 microM. SPC, alone and in combination with insulin, stimulated DNA synthesis in cells known to participate in wound healing, including microvascular endothelial cells. In vivo, SPC stimulated proliferation of keratinocytes, fibroblasts, endothelial cells, and cells around sebaceous glands and hair follicles at day 2-4 postwound, resulting in a complete re- epithelialization and profound granulation tissue formation in excisional and incisional wound sites of db.db and db/+ mice. Quantitative assessment of wound tissue section morphology indicated t...Continue Reading

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Citations

Mar 10, 2006·Pigment Cell Research·Dong-Seok KimKyoung-Chan Park
Mar 16, 2007·Experimental Dermatology·Yoo Bin KwonJeung-Hoon Lee
Nov 25, 2003·Pigment Cell Research·Kazuhiko HiguchiGenji Imokawa
Nov 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kenneth R WattersonSarah Spiegel
Aug 31, 2016·Molecular Medicine Reports·Yong Chan BaeJae Woo Lee
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kwan-Sik KimYan Xu
Jul 25, 2000·The British Journal of Dermatology·K B SuhrH Ogawa
May 16, 2017·Current Dermatology Reports·Dayanjan S WijesingheRobert F Diegelmann
Feb 24, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J S DemoyerM E Durieux
Jun 23, 1997·FEBS Letters·D Meyer zu HeringdorfK H Jakobs
Jun 2, 2000·Biochemical and Biophysical Research Communications·G BoguslawskiD English
Sep 3, 1998·European Journal of Pharmacology·D Meyer zu HeringdorfK H Jakobs
Jun 1, 2000·Biochimica Et Biophysica Acta·A HuwilerK Sandhoff
Apr 16, 1998·The Journal of Investigative Dermatology·N L MarchellW M Holleran
Jan 22, 2003·The Journal of Investigative Dermatology·Krystyna E Rys-SikoraRaymond L Konger
Mar 1, 1997·The Journal of Investigative Dermatology·L SunT B Nielsen
Jul 1, 2006·Biochimica Et Biophysica Acta·Antonio Gómez-Muñoz
May 8, 2007·The International Journal of Biochemistry & Cell Biology·Hyun Jung MoonJae Ho Kim
Nov 10, 2007·Prostaglandins & Other Lipid Mediators·Mijin HanDong-Soon Im
Nov 29, 2007·Progress in Lipid Research·Graeme F NixonIrene Hunter

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