PMID: 2503636May 1, 1989Paper

A newborn rabbit model for total parenteral nutrition: effects of nutritional components on cholestasis

JPEN. Journal of Parenteral and Enteral Nutrition
S HataA Okada

Abstract

A newborn rabbit model for total parenteral nutrition (TPN) was developed to examine the effects of nutritional components on cholestasis. Thirty-five newborn Japanese white rabbits were divided into five groups. Rabbits in group I received glucose-based TPN solution, Group II received lipid-based solution, group III received larger amounts of amino acids than group I, and group IV received larger amounts of nonprotein calories than groups I and II. Rabbits in group V were given mother's milk freely. After the duration of TPN for 7 days, blood samples and liver were obtained when rabbits were killed. In group IV, the serum level of T-Bil (1.44 +/- 0.68 mg/dliter) was significantly higher than those in other groups (group I: 0.28 +/- 0.04 mg/dl; group II: 0.49 +/- 0.12 mg/dl; group III: 0.21 +/- 0.04 mg/dl; group V: 0.28 +/- 0.07 mg/dl), and serum level of GOT (44.2 +/- 25.2 units) and total bile acid (20.6 +/- 8.9 nmol/ml) were significantly higher than those in groups I, II, and III (group I: 16.8 +/- 7.8 units and 6.7 +/- 3.3 nmol/ml, group II: 21.5 +/- 7.9 units and 12.5 +/- 6.4 nmol/ml, group III: 14.3 +/- 4.2 units and 8.4 +/- 5.0 nmol/ml, respectively). Furthermore, there was histological cholestasis characterized by bile...Continue Reading

References

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Citations

Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M OshitaS Tashiro
May 3, 2006·Biological & Pharmaceutical Bulletin·Masuhiro NishimuraAiko Yamauchi
Sep 1, 1996·Digestive Diseases and Sciences·D R DuerksenM T Clandinin
Nov 15, 2006·European Journal of Pediatrics·Jiang WuChenren Shi
Nov 3, 2010·Journal of the American Dietetic Association·Catherine J KleinLouis Scavo
Apr 29, 2015·Gastroenterology Research and Practice·Xueping ZhuJian Wang
Oct 16, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Kunal GuptaSanjiv B Amin
Nov 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·Z J ShuT H Zhang
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Martina KohlInge Bos
Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Patrycja Puiman, Barbara Stoll
Dec 2, 2010·Journal of Pediatric Gastroenterology and Nutrition·Justine M TurnerPaul B Pencharz
Apr 2, 1998·Journal of Pediatric Gastroenterology and Nutrition·M DemircanG Ozok
Jan 1, 1996·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·D ZovkoK L Waag

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