A newly designed curcumin analog Y20 mitigates cardiac injury via anti-inflammatory and anti-oxidant actions in obese rats

PloS One
Yuanyuan QianGuang Liang

Abstract

Obesity is strongly associated with the cause of structural and functional changes of the heart in both human and animal models. Oxidative stress and inflammation play a critical role in the development of obesity-induced cardiac disorders. Curcumin is a natural product from Curcuma Longa with multiple bioactivities. In our previous study, in order to reach better anti-inflammatory and anti-oxidant dual activities, we designed a new mono-carbonyl curcumin analog, Y20, via the structural modification with both trifluoromethyl and bromine. This study was designed to investigate the protective effects of Y20 on obesity-induced cardiac injury and its underlying mechanisms. In high fat diet-fed rats, oral administration of Y20 at 20 mg/kg or curcumin at 50 mg/kg significantly decreased the cardiac inflammation and oxidative stress and eventually improved the cardiac remodeling by mitigating cardiac disorganization, hypertrophy, fibrosis and apoptosis. Y20 at 20 mg/kg showed comparable and even stronger bioactivities than curcumin at 50 mg/kg. The beneficial actions of Y20 are closely associated with its ability to increase Nrf2 expression and inhibit NF-κB activation. Taken together, these results suggest that Y20 may have a great t...Continue Reading

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Citations

Jan 12, 2017·Acta Cirúrgica Brasileira·Melina Ribeiro FernandesRita de Cássia Avellaneda Guimarães
Mar 10, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shuai JiangYang Yang
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Jul 9, 2020·Journal of Cellular and Molecular Medicine·Tien-Hung HuangFan-Yen Lee
Mar 3, 2018·Frontiers in Pharmacology·Ning ZhangQi-Zhu Tang
Dec 4, 2019·The American Journal of Chinese Medicine·Yonghui YuChenglong Wang
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May 5, 2018·Chemical Research in Toxicology·Yaqin LiangLu Cai
Sep 28, 2021··Imanuel Berly Delvis Kapelle, Shielda Natalia Joris

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Methods Mentioned

BETA
column chromatography
PCR
electrophoresis

Software Mentioned

imageJ
GraphPad Pro

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