A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates

The Journal of General Virology
Agathe M G ColmantRoy A Hall

Abstract

A novel flavivirus, provisionally named Bamaga virus (BgV), was isolated from Culex annulirostris mosquitoes collected from northern Australia. Phylogenetic analysis of the complete nucleotide sequence of the BgV genome revealed it clustered with the yellow fever virus (YFV) group, and was most closely related to Edge Hill virus (EHV), another Australian flavivirus, with 61.9 % nucleotide and 63.7 % amino acid sequence identity. Antigenic analysis of the envelope and pre-membrane proteins of BgV further revealed epitopes common to EHV, dengue and other mosquito-borne flaviviruses. However, in contrast to these viruses, BgV displayed restricted growth in a range of vertebrate cell lines with no or relatively slow replication in inoculated cultures. There was also restricted BgV replication in virus-challenged mice. Our results indicate that BgV is an evolutionary divergent member of the YFV group of flaviviruses, and represents a novel system to study mechanisms of virus host-restriction and transmission.

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Citations

Mar 14, 2018·The Journal of General Virology·Natalie A ProwRoy A Hall
Dec 13, 2019·Science Translational Medicine·Jody Hobson-PetersRoy A Hall
Mar 24, 2020·PLoS Neglected Tropical Diseases·Agathe M G ColmantRoy A Hall
Aug 9, 2017·Archives of Virology·Agathe M G ColmantRoy A Hall
Oct 3, 2018·Tropical Medicine and Infectious Disease·Narayan Gyawali, Andrew W Taylor-Robinson
May 28, 2019·Viruses·Nikos VasilakisPeter J Walker
Jan 18, 2017·Evolutionary Bioinformatics Online·Roy A HallJody Hobson-Peters
Jul 9, 2021·The Journal of General Virology·Caitlin A O'BrienRoy A Hall

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