PMID: 9171952Jun 1, 1997Paper

A nitric oxide donor (spermine-NONOate) prevents the formation of neointima in rabbit carotid artery

Clinical and Experimental Pharmacology & Physiology
Z L Yin, G J Dusting

Abstract

1. In the present study we investigated the effect of spermine diazeniumdiolate (spermine-NONOate), a nitric oxide donor, on the early development of atheroma-like lesions induced by a peri-arterial collar in rabbits. 2. Spermine-NONOate was given locally by incorporating the compound (1 mg/mL) into a silastic collar, which was applied on one common carotid artery of rabbit while the other carotid artery had a placebo collar (without compound) applied. 3. Fourteen days postimplantation, both carotid arteries were dissected free for histological study (n = 6). 4. After 14 days with collars, treatment with spermine-NONOate had significantly reduced (by 74%) the thickness of the neointima in comparison with the contralateral collared artery without compound. Blood pressure did not change during treatment. Nitric oxide, detected as nitrite, was still released from spermine-NONOate silastic collars after 14 days implantation. 5. These results suggest that locally administered spermine-NONOate is effective in slowing the development of neointima in this model.

References

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Jun 1, 1995·Clinical and Experimental Pharmacology & Physiology·J F ArthurG J Dusting

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Citations

Sep 30, 1999·Molecular Biotechnology·D M Morgan
Aug 12, 1999·European Journal of Pharmacology·H BultK E Matthys
Dec 19, 2000·Free Radical Biology & Medicine·D R Janero, J F Ewing
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Nov 11, 1998·Clinical and Experimental Pharmacology & Physiology. Supplement·G J DustingV Gurevich
Oct 18, 2003·Experimental Animals·Bulent DuranAyse Gonca Imir
Aug 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·G R De MeyerH Bult
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Pasquale MaffiaGiuseppe Cirino
May 15, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lakeshia J TaiteJennifer L West
Dec 16, 2005·American Journal of Physiology. Cell Physiology·Alice-Corina CeacareanuAviv Hassid
Oct 4, 2008·Biomacromolecules·Achala de MelAlexander M Seifalian
Dec 19, 2002·Vascular Pharmacology·Guilia RussoJoseph Loscalzo

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