A nomogram for predicting the benefit of adjuvant cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma

Scientific Reports
Qiu-Zhong PanJian-Chuan Xia

Abstract

The benefits of adjuvant cytokine-induced killer (CIK) cell immunotherapy for hepatocellular carcinoma (HCC) remain mixed among patients. Here, we constructed a prognostic nomogram to enable individualized predictions of survival benefit of adjuvant CIK cell treatment for HCC patients. Survival analysis showed that the median overall survival (OS) and progression-free survival (PFS) for patients in the hepatectomy/CIK combination group were 41 and 16 months, respectively, compared to 28 and 12 months for patients in the hepatectomy alone group (control). Based on multivariate analysis of the entire cohort, independent factors for OS were tumor size, tumor capsule, pathological grades, total bilirubin, albumin, prothrombin time, alpha-fetoprotein, and tumor number, which were incorporated into the nomogram. The survival prediction model performed well, as assessed by the c-index and calibration curve. Internal validation revealed a c-index of 0.698, which was significantly greater than the c-index value of the TNM (tumor-node-metastasis) staging systems of 0.634. The calibration curves fitted well. In conclusions, our developed nomogram resulted in more accurate individualized predictions of the survival benefit from adjuvant CI...Continue Reading

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Citations

Feb 9, 2010·Journal of Ethnopharmacology·Yiwen ZhengCynthia L Darlington
Aug 26, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasunari Nakamoto
Jan 20, 2019·Frontiers of Medicine·Renyu ZhangZhinan Chen
Mar 6, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Chern-Horng LeeSen-Yung Hsieh
Dec 18, 2020·Seminars in Interventional Radiology·Hanna JavanNadine Abi-Jaoudeh
Aug 28, 2021·Cells·Farhan Z IlyasTimothy M Pawlik

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Methods Mentioned

BETA
imaging techniques
biopsy

Software Mentioned

R
Hmisc
SPSS

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