A Nomogram to Predict Anastomotic Leakage in Open Rectal Surgery-Hope or Hype?

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Johannes KloseAlexis Ulrich

Abstract

Anastomotic leakage is the most dreaded complication after rectal resection and total mesorectal excision, leading to increased morbidity and mortality. Formation of a diverting ileostomy is generally performed to protect anastomotic healing. Identification of variables predicting anastomotic leakage might help to select patients who are under increased risk for the development of anastomotic leakage prior to surgery. The objective of this study was to assess the applicability of a nomogram as prognostic model for the occurrence of anastomotic leakage after rectal resection in a cohort of rectal cancer patients. Nine hundred seventy-two consecutive patients who underwent surgery for rectal cancer were retrospectively analyzed. Univariate and multivariable Cox regression analyses were used to determine independent risk factors associated with anastomotic leakage. Receiver operating characteristics (ROC) curve analysis was performed to calculate the sensitivity, specificity, and overall model correctness of a recently published nomogram and an adopted risk score based on the variables identified in this study as a predictive model. Male sex (p = 0.042), obesity (p = 0.017), smoking (p = 0.012), postoperative bleeding (p = 0.024),...Continue Reading

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Citations

Jan 9, 2022·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Izel OzmenUNKNOWN LekCheck Study Group

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