A non-archimedean theory of interaction of chemical compounds with membranes

Bio Systems
O IordacheP T. Frangopol

Abstract

The permeability of procaine across axon membranes and the effect of formaldehyde (FA), crotonic aldehyde (CA) and glutaraldehyde (GA) on the compound action potential of frog sciatic nerve was studied by utilizing a non-archimedean (NA) model of the relaxation process. Such models allow a characterization of biosystems exhibiting more than one time scale. Expansions using Laguerre polynomials have been obtained for relaxation functions. The new approach is tested by fitting the model to the experimental data of other authors, and then applying to extract molecular level information from macroscopic data.

References

Jul 28, 1977·Nature·D A HaydonJ Requena
Jan 18, 1989·Biochimica Et Biophysica Acta·H Meves, K Nagy
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A AnsariR D Young
Jan 1, 1985·The Journal of Membrane Biology·J RequenaJ D Medina
May 1, 1981·Archives internationales de physiologie et de biochimie·D G MargineanuJ Popa
May 6, 1981·Biochimica Et Biophysica Acta·S OhkiH Pant

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Citations

Jul 5, 2001·Colloids and Surfaces. B, Biointerfaces·P T. Frangopol, D Mihăilescu

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