A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices

Cell Reports
Genki MinamisawaDaniel H O'Connor

Abstract

Sensory perception depends on interactions among cortical areas. These interactions are mediated by canonical patterns of connectivity in which higher areas send feedback projections to lower areas via neurons in superficial and deep layers. Here, we probed the circuit basis of interactions among two areas critical for touch perception in mice, whisker primary (wS1) and secondary (wS2) somatosensory cortices. Neurons in layer 4 of wS2 (S2L4) formed a major feedback pathway to wS1. Feedback from wS2 to wS1 was organized somatotopically. Spikes evoked by whisker deflections occurred nearly as rapidly in wS2 as in wS1, including among putative S2L4 → S1 feedback neurons. Axons from S2L4 → S1 neurons sent stimulus orientation-specific activity to wS1. Optogenetic excitation of S2L4 neurons modulated activity across both wS2 and wS1, while inhibition of S2L4 reduced orientation tuning among wS1 neurons. Thus, a non-canonical feedback circuit, originating in layer 4 of S2, rapidly modulates early tactile processing.

Citations

Nov 2, 2019·Nature·Julie A HarrisHongkui Zeng
Aug 2, 2019·Nature Reviews. Neuroscience·Carl C H Petersen
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Feb 2, 2021·ELife·Hedi YoungLeopoldo Petreanu
Feb 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Michael WenzelRafael Yuste
Mar 6, 2021·PeerJ·Thomas F Burns, Ramesh Rajan
Apr 29, 2021·The Journal of Comparative Neurology·Courtney Michelle WhildenSolange Pezon Brown
Oct 6, 2021·Scientific Reports·M Di Volo, I Férézou

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

ksdensity
WaveSurfer
Adobe Photoshop
MATLAB
MATLAB signtest
MATLAB perfcurve

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