A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Nature Communications
Jlenia GuarnerioPier Paolo Pandolfi

Abstract

Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit+ leukemic cells non-cell autonomously.

References

Feb 8, 2002·Cell·Paolo Salomoni, Pier Paolo Pandolfi
Apr 2, 2005·Nature Reviews. Cancer·Brian J P Huntly, D Gary Gilliland
Jul 25, 2006·Nature·Andrei V KrivtsovScott A Armstrong
May 13, 2008·Nature·Keisuke ItoPier Paolo Pandolfi
Apr 3, 2009·Genes & Development·Johannes ZuberScott W Lowe
Mar 23, 2010·Nature·Marc H G P RaaijmakersDavid T Scadden
Jul 3, 2010·Genes & Development·Zhen ZhaoScott W Lowe
Dec 18, 2012·Blood·Stephen J Forman, Jacob M Rowe
Jan 10, 2013·Annual Review of Immunology·Paul S FrenetteChristoph Scheiermann
Oct 11, 2013·Nature·Yuya KunisakiPaul S Frenette
Oct 29, 2013·Nature Medicine·Daniela S KrauseDavid T Scadden
Jan 21, 2014·Cell Stem Cell·Lev M KatsPier Paolo Pandolfi
Feb 28, 2014·Frontiers in Oncology·Rosa Bernardi, Pier Paolo Pandolfi
Jun 18, 2014·Cancer Cell·Cai-Wen DuanDeng-Li Hong
Mar 10, 2015·Cell Stem Cell·Koen SchepersEmmanuelle Passegué
Jan 18, 2018·Nature Genetics·Ming ChenPier Paolo Pandolfi

❮ Previous
Next ❯

Citations

Aug 3, 2018·Annals of Hematology·Erika Costa de AlvarengaAlexander Birbrair
Jan 8, 2020·Nature Cell Biology·Antoniana BatsivariDominique Bonnet
Oct 2, 2019·Cell Death and Differentiation·Leire ArrealArkaitz Carracedo
Jan 6, 2021·Cells·Neerajana DattaMrinal K Ghosh
May 9, 2021·Cancer Gene Therapy·Georgios Giamas, Teresa Gagliano
May 13, 2021·Cell Reports·Diana PassaroDominique Bonnet

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
transgenic
ELISA
FACS
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

[Rinshō ketsueki] The Japanese journal of clinical hematology
Ryosuke Uchibori, Keiya Ozawa
[Rinshō ketsueki] The Japanese journal of clinical hematology
Kazuhito Naka
© 2022 Meta ULC. All rights reserved