A non-human primate system for large-scale genetic studies of complex traits.

Human Molecular Genetics
Anna J JasinskaNelson B Freimer

Abstract

Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) are genetically homogeneous and large enough to permit well-powered genetic mapping studies of quantitative traits relevant to human health, including expression quantitative trait loci (eQTL). Previous transcriptome-wide investigation in an extended vervet pedigree identified 29 heritable transcripts for which levels of expression in peripheral blood correlate strongly with expression levels in the brain. Quantitative trait linkage analysis using 261 microsatellite markers identified significant (n = 8) and suggestive (n = 4) linkages for 12 of these transcripts, including both cis- and trans-eQTL. Seven transcripts, located on different chromosomes, showed maximum linkage to markers in a single region of vervet chromosome 9; this observation suggests the possibility of a master trans-regulator locus in this region. For one cis-eQTL (at B3GALTL, beta-1,3-glucosyltransferase), we conducted follow-up single nucleotide polymorphism genotyping and fine-scale association analysis in a sample of unrelated Caribbean vervets, localizing thi...Continue Reading

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Citations

Aug 27, 2013·Theoretical Population Biology·Montgomery Slatkin
Nov 1, 2013·ILAR Journal·Eric J Vallender, Gregory M Miller
Nov 1, 2013·ILAR Journal·Anna J JasinskaNelson B Freimer
Apr 9, 2014·Nature Reviews. Genetics·Jeffrey Rogers, Richard A Gibbs
Mar 25, 2014·Annals of the New York Academy of Sciences·J David JentschZachary T Pennington
Apr 23, 2013·Neurobiology of Aging·Sergey KalininDouglas L Feinstein
Nov 6, 2015·American Journal of Primatology·Matthew J JorgensenJames L Weed
Jul 1, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan K RhoadsJeffrey L Osborn
May 29, 2015·Journal of Virology·Benjamin B PolicicchioCristian Apetrei
May 29, 2015·Journal of Virology·Beatrix KapusinszkyEric Delwart
Oct 1, 2021·GeroScience·Anna J JasinskaSteve Horvath
Sep 18, 2015·Genome Research·Wesley C WarrenNelson B Freimer

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