PMID: 15383569Sep 24, 2004Paper

A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor

The Journal of Immunology : Official Journal of the American Association of Immunologists
Eugene Y Chiang, I Stroynowski

Abstract

Although CTL and polymorphic, classical MHC class I molecules have well defined roles in the immune response against tumors, little is currently known regarding the participation of nonpolymorphic, nonclassical MHC class I in antitumor immunity. Using an MHC class I-deficient melanoma as a model tumor, we demonstrate that Q9, a murine MHC class Ib molecule from the Qa-2 family, expressed on the surface of tumor cells, protects syngeneic hosts from melanoma outgrowth. Q9-mediated protective immunity is lost or greatly diminished in mice deficient in CTL, including beta(2)-microglobulin knockout (KO), CD8 KO, and SCID mice. In contrast, the Q9 antitumor effects are not detectably suppressed in CD4 KO mice with decreased Th cell activity. Killing by antitumor CTL in vitro is Q9 specific and can be blocked by anti-Q9 and anti-CD8 Abs. The adaptive Q9-restricted CTL response leads to immunological memory, because mice that resist the initial tumor challenge reject subsequent challenges with less immunogenic tumor variants and show expansion of CD8(+) T cell populations with an activated/memory CD44(high) phenotype. Collectively, these studies demonstrate that a MHC class Ib molecule can serve as a restriction element for antitumor C...Continue Reading

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Citations

Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene Y Chiang, Iwona Stroynowski
Dec 24, 2018·Frontiers in Immunology·Istéfani L da SilvaMiguel Quintanilla
May 12, 2007·European Journal of Immunology·Ana GoyosJacques Robert
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eugene Y Chiang, Iwona Stroynowski
Apr 30, 2014·Carcinogenesis·Nikesha Haynes-GilmoreJacques Robert
Jun 11, 2008·The Journal of Experimental Medicine·Phillip A SwansonAron E Lukacher
Nov 8, 2006·The Journal of Experimental Medicine·Gobardhan DasYufang Shi
Jun 8, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Istéfani Luciene da SilvaEnio Ferreira
Dec 7, 2007·Journal of Reproductive Immunology·Paula W LamptonCarol M Warner

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