A nonclonal outbreak of vancomycin-sensitive Enterococcus faecalis bacteremia in a neonatal intensive care unit

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Despina KotsanasRhonda L Stuart

Abstract

To describe an outbreak of bacteremia caused by vancomycin-sensitive Enterococcus faecalis (VSEfe). An investigation by retrospective case control and molecular typing by whole-genome sequencing (WGS). A tertiary-care neonatal unit in Melbourne, Australia. Risk factors for 30 consecutive neonates with VSEfe bacteremia from June 2011 to December 2014 were analyzed using a case control study. Controls were neonates matched for gestational age, birth weight, and year of birth. Isolates were typed using WGS, and multilocus sequence typing (MLST) was determined. Bacteremia for case patients occurred at a median time after delivery of 23.5 days (interquartile range, 14.9-35.8). Previous described risk factors for nosocomial bacteremia did not contribute to excess risk for VSEfe. WGS typing results designated 43% ST179 as well as 14 other sequence types, indicating a polyclonal outbreak. A multimodal intervention that included education, insertion checklists, guidelines on maintenance and access of central lines, adjustments to the late onset sepsis antibiotic treatment, and the introduction of diaper bags for disposal of soiled diapers after being handled inside the bed, led to termination of the outbreak. Typing using WGS identified...Continue Reading

References

Aug 1, 2006·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Tânia Mara Varejão StrabelliDavid Everson Uip
Jun 12, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Srabani SamantaPaul T Heath
Mar 17, 2012·Nature Reviews. Microbiology·Cesar A Arias, Barbara E Murray
Sep 12, 2014·Scientific Reports·Patrick VeigaSean P Kennedy
Jan 13, 2015·Trends in Molecular Medicine·Noel T MuellerMaria G Dominguez-Bello
Jul 21, 2015·American Journal of Infection Control·David M ListerRhonda L Stuart
Jan 10, 2017·American Journal of Infection Control·Elizabeth GillespieRhonda L Stuart
Mar 12, 2017·European Journal of Pediatrics·Jacqueline E TaylorKenneth Tan
May 10, 2017·Journal of the Chinese Medical Association : JCMA·Yong-Chuan ChenFang-Liang Huang
Jun 6, 2017·Current Opinion in Infectious Diseases·Julia Johnson, Caroline Quach
Jun 2, 2018·Microbiome·Noelle E YoungePatrick C Seed
Nov 15, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Joanna WangUNKNOWN neonIN network

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Bacteriologia, virusologia, parazitologia, epidemiologia
Ioan BacilaOctavian Popescu
The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Ozden TurelRengin Siraneci
© 2021 Meta ULC. All rights reserved