PMID: 11902880Mar 21, 2002Paper

A noncovalent approach to antiparallel beta-sheet formation

Journal of the American Chemical Society
H ZengBing Gong

Abstract

Four tripeptide chains, when attached to the same end of a hydrogen-bonded duplex (1.2) with the unsymmetrical, complementary sequences of ADAA/DADD, have been brought into proximity, leading to the formation of four hybrid duplexes, 1a.2a, 1a.2b, 1b.2a, and 1b.2b, each of which contains a two-stranded beta-sheet segment. The extended conformations of the peptide chains were confirmed by 1D and 2D NMR. The peptide strands stay registered through hydrogen bonding and the beta-sheets are stabilized by side chain interactions. Two-dimensional NMR data also indicate that the duplex template prevents further aggregation in the peptide segment. When the peptide chains are attached to the two different termini of the duplex template, NMR studies show the presence of a mixture with no clearly defined conformations. In the absence of the duplex template, the tripeptides are found to associate randomly. Finally, isothermal titration calorimetry studies revealed that the hybrid duplex 1a.2a was more stable than either the duplex template or the peptides alone.

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Citations

May 15, 2012·Accounts of Chemical Research·Bing Gong
Feb 14, 2007·Journal of the American Chemical Society·R Jeremy WoodsJames S Nowick
May 10, 2012·Journal of the American Chemical Society·Hidekazu YamadaEiji Yashima
Apr 2, 2009·Journal of the American Chemical Society·Hidetoshi GotoEiji Yashima
Jul 3, 2010·The Journal of Organic Chemistry·Sujeewa RanatungaJuan R Del Valle
Feb 4, 2010·Chemical Communications : Chem Comm·Jiahui ZhangBing Gong
Aug 19, 2011·Chemical Communications : Chem Comm·Arup RoyGangadhar J Sanjayan
Apr 7, 2004·European Journal of Biochemistry·Adam R SanfordBing Gong
Aug 18, 2004·Current Opinion in Structural Biology·Richard P Cheng
Jan 21, 2004·Journal of Molecular Recognition : JMR·Matthew J Cliff, John E Ladbury
May 13, 2015·Chemistry, an Asian Journal·Paloth Venugopalan, Raghuvansh Kishore
Jan 16, 2009·Macromolecular Rapid Communications·Julien BernardBernard Fenet
May 8, 2010·Chemical Society Reviews·Andrew J Wilson
May 23, 2012·Organic & Biomolecular Chemistry·Maria L PellizzaroAndrew J Wilson
Nov 9, 2012·Macromolecular Rapid Communications·Arthur BertrandJulien Bernard
Sep 17, 2013·Chemical Communications : Chem Comm·Davoud Mozhdehi, Zhibin Guan
Jan 1, 2012·ISRN Biochemistry·Hang Yin
Jan 22, 2005·Angewandte Chemie·Xiaowu Yang, Bing Gong
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuele Rinaldi
Apr 29, 2009·The Journal of Physical Chemistry. B·Zhiwei LiuVojislava Pophristic
Feb 26, 2005·The Journal of Organic Chemistry·Scott T PhillipsPaul A Bartlett
Dec 4, 2004·Angewandte Chemie·Xiaowu YangChang Y Ryu
Aug 11, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Zhi LiuYong Huang
Mar 7, 2018·Organic Letters·Yukun ZhangBing Gong
Feb 5, 2014·ACS Chemical Biology·Geronda L MontalvoWilliam F Degrado
Dec 17, 2005·The Journal of Organic Chemistry·Lihua YuanBing Gong
Aug 14, 2003·Journal of the American Chemical Society·Xiaowu YangBing Gong
Mar 27, 2003·Journal of the American Chemical Society·Jian R LuJeff Penfold

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