A nonfunctioning parathyroid carcinoma misdiagnosed as a follicular thyroid nodule

World Journal of Surgical Oncology
Filomena CetaniClaudio Marcocci

Abstract

Parathyroid carcinoma (PC) is a rare endocrine malignancy. The tumor is mostly functioning, causing severe primary hyperparathyroidism, with high serum calcium and parathyroid hormone (PTH) levels. Nonfunctioning PC is extremely rare. We report a 50-year-old male patient who was referred to our Department for a right thyroid nodule, incidentally detected on carotid Doppler ultrasound scan, with a fine-needle aspiration cytology showing a follicular lesion. At the time of our evaluation, neck ultrasound showed a 1.3 cm right hypoechoic thyroid nodule with irregular margins and the absence of enlarged bilateral cervical lymph nodes. Thyroid function tests were normal. Serum calcium was normal and plasma PTH slightly above the upper limit of the normal range. The patients underwent right lobectomy. The intraoperative frozen-section pathological examination raised the suspicion of a PC. Definitive histology showed a markedly irregular infiltrative growth of the tumor with invasion of the thyroid tissue and cervical soft tissues. Immunostaining for thyroglobulin was negative, whereas staining for chromogranin A and PTH showed a strong reactivity. Based on the microscopic findings and the immunohistochemical profile, the tumor was di...Continue Reading

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Citations

Mar 24, 2016·Journal of Endocrinological Investigation·F CetaniC Marcocci
Oct 17, 2016·Endocrine·Alfredo CampennìSergio Baldari
Jun 2, 2020·Endocrine Journal·Masao TakenobuHiroya Kitano
Feb 22, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·A CaleoP Zeppa
May 13, 2021·Surgical Case Reports·Masaomi SenKaori Kameyama

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