PMID: 8962520Oct 1, 1996Paper

A nonidentifiability aspect of the two-stage model of carcinogenesis

Risk Analysis : an Official Publication of the Society for Risk Analysis
Leonid Hanin, Yakovlev AYu

Abstract

This paper discusses identifiability of the two-stage birth-death-mutation model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model parameters cannot be uniquely estimated from time-to-tumor observations.

References

Jun 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H Moolgavkar, G Luebeck
Jun 1, 1981·Journal of the National Cancer Institute·S H Moolgavkar, A G Knudson
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·A Kopp-SchneiderC D Sherman
Dec 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·Q Zheng
Aug 1, 1993·Mathematical Biosciences· Yakovlev AYuL Bass
Jan 1, 1993·Mathematical Biosciences·L B Klebanov Yakovlev AYu
May 1, 1996·Radiation and Environmental Biophysics·W F Heidenreich

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Citations

Jan 10, 2002·Mathematical Biosciences·Giovanni GregoriAndrei Yakovlev
Jun 1, 1997·Mathematical Biosciences·A YakovlevE Polig
Nov 14, 1997·Mathematical Biosciences·D Wiarda, C C Travis
Aug 31, 1999·Mathematical Biosciences·L G Hanin, K M Boucher
Feb 1, 2000·Mathematical Biosciences·M V Smith, C J Portier
Oct 24, 2001·Mutation Research·I M van Leeuwen, C Zonneveld
Mar 14, 2002·Biometrics·David B Dunson, Donna D Baird
Jul 23, 2008·Theoretical Biology & Medical Modelling·Sandro Gsteiger, Stephan Morgenthaler
May 12, 2000·Environmental Health Perspectives·C W Chen
Jun 1, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·C D Sherman, C J Portier
Jul 19, 2012·Statistics in Medicine·Leonid Hanin, Lyudmila Pavlova
Aug 26, 2006·Journal of Theoretical Biology·Leonid HaninMarco Zaider
Sep 21, 2005·Journal of Theoretical Biology·Leonid HaninAndrei Yakovlev
Aug 10, 2005·Mathematical Biosciences·Rafael MezaSuresh H Moolgavkar
Aug 5, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Leonid Hanin, Jason Rose
Oct 18, 2000·Journal of Theoretical Biology·P F Pinsky
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Georg Luebeck, William D Hazelton
Feb 3, 1998·Statistical Methods in Medical Research·A Kopp-Schneider
Feb 3, 1998·Statistical Methods in Medical Research·C Portier, H el Masri

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