PMID: 9163635May 1, 1997Paper

A noninvasive electromyographic study on threshold and intensity of cough in humans

The European Respiratory Journal
Giovanni A FontanaP Panuccio

Abstract

The assessment of cough threshold and intensity is important in respiratory medicine. We have developed a method for objectively and noninvasively assessing cough threshold and intensity of expiratory muscle efforts in response to inhalation of ultrasonically nebulized distilled water (UNDW). Thirty (83%) out of 36 volunteers studied coughed in response to UNDW inhalation. Cough threshold was taken as the lowest nebulizer output (mL x min(-1)) that induced cough in two challenges performed at a 30 min interval. At threshold level, repeatability of peak and slope of the integrated electromyographic (IEMG) activity of abdominal muscles was evaluated. Short- and long-term repeatability of cough threshold were evaluated in 15 subjects following a 3 h and a 6-9 month interval, respectively. Dose-response relationships between nebulizer outputs and IEMG-related variables were also investigated, as were the correlations between the latter and expiratory flow during voluntary coughing. The median (1st and 3rd quartile) cough threshold value was 0.89 (0.40 and 1.54) mL x min(-1). At threshold level, peak and slope of IEMG activity were highly reproducible. Cough threshold displayed a high degree of short- and long-term repeatability. Pe...Continue Reading

Citations

Oct 3, 2007·Lung·Giovanni A Fontana
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·G A FontanaS Gangemi
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·G A FontanaM Pistolesi
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·F LavoriniM Pistolesi
Aug 4, 2007·American Journal of Respiratory and Critical Care Medicine·Federico LavoriniJohn Widdicombe
Oct 12, 2012·Odontology·Yoko WakasugiHiroshi Uematsu
Jan 29, 2011·Pulmonary Pharmacology & Therapeutics·Chiara MagniJohn Widdicombe
Nov 26, 2010·Chest·Federico LavoriniJohn Widdicombe
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·Jaclyn Smith
Dec 1, 2006·Respiratory Physiology & Neurobiology·Federico LavoriniGiovanni A Fontana
Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·Giovanni A FontanaRaffaele Piumelli
May 8, 2020·American Journal of Speech-language Pathology·Emma WallacePhoebe Macrae
Jul 16, 2020·International Journal of Speech-language Pathology·Emma WallaceMaggie-Lee Huckabee
Dec 7, 2011·The Journal of Physiology·Jaclyn A SmithPeter M Calverley
Jan 23, 2010·Journal of Applied Physiology·Federico LavoriniJohn Widdicombe
Aug 6, 2020·Journal of Physical Therapy Science·Yukako SetakaKazuhide Tomita
Apr 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyue NiJohn A Rogers

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